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Neural Plasticity
Volume 2007, Article ID 73754, 7 pages
Review Article

Hippocampal Neurogenesis, Depressive Disorders, and Antidepressant Therapy

1INSERM, U677, Paris 75013, France
2Faculté de Médecine Pierre et Marie Curie, Université Pierre et Marie Curie-Paris 6, Site Pitié-Salpêtrière, IFR 70 des Neurosciences, UMR S677, Paris 75013, France

Received 30 November 2006; Accepted 5 March 2007

Academic Editor: Georges Chapouthier

Copyright © 2007 Eleni Paizanis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


There is a growing body of evidence that neural stem cells reside in the adult central nervous system where neurogenesis occurs throughout lifespan. Neurogenesis concerns mainly two areas in the brain: the subgranular zone of the dentate gyrus in the hippocampus and the subventricular zone, where it is controlled by several trophic factors and neuroactive molecules. Neurogenesis is involved in processes such as learning and memory and accumulating evidence implicates hippocampal neurogenesis in the physiopathology of depression. We herein review experimental and clinical data demonstrating that stress and antidepressant treatments affect neurogenesis in opposite direction in rodents. In particular, the stimulation of hippocampal neurogenesis by all types of antidepressant drugs supports the view that neuroplastic phenomena are involved in the physiopathology of depression and underlie—at least partly—antidepressant therapy.