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Neural Plasticity
Volume 2007, Article ID 90472, 14 pages
http://dx.doi.org/10.1155/2007/90472
Research Article

Autobiographical Memory Retrieval and Hippocampal Activation as a Function of Repetition and the Passage of Time

Department of Psychology, University of Arizona, Tucson, AZ 85721, USA

Received 17 April 2007; Revised 4 September 2007; Accepted 8 October 2007

Academic Editor: Leonardo G. Cohen

Copyright © 2007 Lynn Nadel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Multiple trace theory (MTT) predicts that hippocampal memory traces expand and strengthen as a function of repeated memory retrievals. We tested this hypothesis utilizing fMRI, comparing the effect of memory retrieval versus the mere passage of time on hippocampal activation. While undergoing fMRI scanning, participants retrieved remote autobiographical memories that had been previously retrieved either one month earlier, two days earlier, or multiple times during the preceding month. Behavioral analyses revealed that the number and consistency of memory details retrieved increased with multiple retrievals but not with the passage of time. While all three retrieval conditions activated a similar set of brain regions normally associated with autobiographical memory retrieval including medial temporal lobe structures, hippocampal activation did not change as a function of either multiple retrievals or the passage of time. However, activation in other brain regions, including the precuneus, lateral prefrontal cortex, parietal cortex, lateral temporal lobe, and perirhinal cortex increased after multiple retrievals, but was not influenced by the passage of time. These results have important implications for existing theories of long-term memory consolidation.