Dopaminergic Suppression of Synaptic Transmission in the Lateral Entorhinal Cortex
Figure 1
Dopamine has dose-dependent and
bidirectional effects on the amplitude of mixed EPSPs in layer II fan
cells. (a) Fifty M dopamine
significantly reduces the amplitude of synaptic responses. Traces show averaged EPSPs before (ACSF) and
after 5-minute bath application of dopamine (DA) in a representative cell. Group data indicate the mean amplitude of
EPSPs before and after dopamine (*,). Bars indicate ±1 SEM in this and subsequent
figures, and * indicates unless otherwise indicated. (b) A lower concentration of 10 M dopamine
causes a smaller suppression of synaptic responses. (c) The low 1 M concentration of dopamine enhances
the amplitude of synaptic responses (*,). (d) Bath
application of vehicle (50 M sodium metabisulfite; Veh) does not significantly
affect synaptic transmission.
