Dopaminergic Suppression of Synaptic Transmission in the Lateral Entorhinal Cortex
Figure 3
Dopamine suppresses
the amplitude of both AMPA- and NMDA receptor-mediated components of
EPSPs. (a) AMPA-mediated EPSPs
recorded in the presence of APV and bicuculline were suppressed by 50 M
dopamine. Averaged traces show EPSPs
recorded before (BL) and after (DA) dopamine application, and group data are
shown at right. (b) Isolated NMDA
receptor-mediated EPSPs recorded in the presence of CNQX and bicuculline are
also suppressed by a high concentration of dopamine. Group data show a consistent suppression of
the small isolated NMDA response.
