Dopaminergic Suppression of Synaptic Transmission in the Lateral Entorhinal Cortex
Figure 4
Dopamine suppresses
isolated AMPA-mediated EPSPs via a D2 receptor-dependent
mechanism. (a) Coapplication of the D1 receptor antagonist SCH23390 (50 M) did not prevent the dopamine-induced
reduction in EPSP amplitude. (b) However, coapplication of the D2 receptor antagonist
sulpiride (50 M) significantly attenuated the dopaminergic suppression of
EPSPs. Sulpiride also prevented the
enhancement of paired-pulse facilitation induced by dopamine (b2).
