Linking Cellular Mechanisms to Behavior: Entorhinal Persistent Spiking and Membrane Potential Oscillations May Underlie Path Integration, Grid Cell Firing, and Episodic Memory
Figure 2
(a) Example of graded
persistent firing in a layer V pyramidal cell from Egorov et al. [8]. (b) Simulation of grid
cell firing based on persistent firing in cells from deep layers of
medial entorhinal cortex. The spiking
activity shown as black dots arises from convergent input from three neurons
with the same baseline persistent firing frequency, with phase of input neurons
influenced by input from different speed modulated head direction cells during
movement (trajectory shown in gray). (c)
Simulation of grid cell firing based on membrane potential oscillations in
dorsal layer II stellate cells in medial entorhinal cortex.
