Differential Induction of Long-Term Potentiation in the Horizontal versus Columnar Superficial Connections to Layer II Cells of the Entorhinal Cortex
Figure 12
Induction of LTP in the ascending
pathway was not dependent upon intact CaMKII signalling. (a) Normalized scaled amplitude of peak EPSCs evoked by test pulses
in a layer II cell is plotted against time. Time point of application of 3.8M
KN62 is indicated by the line. HFS led to only a slight short-term potentiation
(PTP) but a prominent long-term potentiation. The inset shows two traces reflecting
averaged EPSCs at baseline (pre-HFS) and at 30 minutes post-HFS. (b) Average normalized scaled amplitude
of peak EPSCs across 10 cells in the presence of KN62 as indicated by the line.
The value 30 minutes after HFS was which was significantly
different from baseline values () and no different from LTP in
control conditions ().
