Differential Induction of Long-Term Potentiation in the Horizontal versus Columnar Superficial Connections to Layer II Cells of the Entorhinal Cortex
Figure 8
Induction of LTP in the ascending
pathway did not require activation of NMDA-receptors. (a) Normalized scaled amplitude of peak EPSCs evoked by test pulses
in a layer II cell is plotted against time. Time point of application of 50M
DL-APV is indicated by the line (note, all experiments involved superfusions of
APV for more than 10 minutes before application of HFS at time zero). HFS led
to both short-term (PTP) and long-term potentiation. The inset shows two traces
reflecting averaged EPSCs at baseline (pre-HFS) and at 30 minutes post-HFS. (b) Average normalized scaled amplitude
of peak EPSCs across 10 cells in the presence of APV as indicated by the line. The
value 30 and 50 minutes after was and , respectively,
which were both significantly different from baseline values ().
