Dendritic Spines and Development: Towards a Unifying Model of Spinogenesis—A Present Day Review of Cajal's Histological Slides and Drawings
Figure 3
Models of spinogenesis based on the Figure 3 from Yuste and Bonhoeffer [14]. (a) Sotelo model: dendritic spines emerge from dendritic trees by an autonomous cellular program, independently of the axonal terminals. (b) Miller/Peters model: dendritic spines are induced by axonal terminals on dendrites by a successive outgrowth through a sessile spine to a pedunculated one. (c) Filopodial model : filopodia become dendritic spines interacting with axons. Synaptic contacts in green.
(a) Sotelo model (dendritic spines in Purkinje cells)
(b) Miller/Peter model (dendritic spines in cerebral cortex)
