Dendritic Spines and Development: Towards a Unifying Model of Spinogenesis—A Present Day Review of Cajal's Histological Slides and Drawings

Figure 7

(a) Illustrates a scientific drawing by Cajal [7, Figure 418]. Purkinje cells, cerebellum, newborn child, and Golgi method. Supernumerary collaterals of the Purkinje axon (A); inferior collaterals (C); soma with indifferent appendages (a); formation of the definitive branches (b); inset shows dendritic spines digitally enlarged of the boxed region. (b) Purkinje cell; from left to right, perisomatic spines synapsing (Ss) on climbing fibers (c); dendritic spines (Ds) of large dendrites synapsing on climbing fibers (c); dendritic spines of Purkinje cell dendritic branchlets that synapses on parallel fibers (p; [21]). (c) sketch of the evolution of the climbing fibers and dendritic spines based on electron microscopy observations [15]. (d) cluster of dendritic spines (spcf) connecting with a climbing fiber (cf) [22].