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Neural Plasticity
Volume 2010 (2010), Article ID 769207, 29 pages
http://dx.doi.org/10.1155/2010/769207
Review Article

Dendritic Spines and Development: Towards a Unifying Model of Spinogenesis—A Present Day Review of Cajal's Histological Slides and Drawings

Department of Molecular, Cellular and Developmental Neurobiology, Instituto Cajal, CSIC, Avenida Doctor Arce 37, 28002 Madrid, Spain

Received 23 September 2010; Accepted 14 November 2010

Academic Editor: Michael Stewart

Copyright © 2010 Pablo García-López et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Video 1 is a moving 3D–model showing the possible role of filopodia in the processes of synaptogenesis and spinogenesis.

Seven videos illustrate and complement the descriptions and figures of the text by means of rotation, translation and scaling of 3D–reconstructions made from optical serial sections of the histological preparations of Santiago Ramón y Cajal:

Video 2 shows the figure 16 (a): a layer III pyramidal cell of a newborn rabbit; filopodia and protospines are color coded in green.

Video 3 shows figure 16(d): layer III pyramidal cell of a young mouse. The last frames of video 2 and video 3 show a comparison of the 3D–image obtained using the Golgi method and the stack of images of living tissue using two–photon confocal microscopy.

Video 4 depicts figure 18(a): a granule cell of the olfactory bulb, one–month–old dog. Filopodia and protospines are color coded in green.

Video 5 shows figure 19(c): a young immature granule cell of the cerebellum, newborn cat. Filopodia and protospines are color coded in green.

Video 5 shows figure 19(c): a young immature granule cell of the cerebellum, newborn cat. Filopodia and protospines are color coded in green.

Video 7 shows figure 19(e): a double bouquet cell of the motor cortex, layer III, one–month–old child. Filopodia and protospines are color coded in green.

Video 8 shows figure 19(f): a basket cell of the motor cerebral cortex, layer IV, one–month–old dog. Filopodia and protospines are color coded in green.

  1. Supplementary Video 1
  2. Supplementary Video 2
  3. Supplementary Video 3
  4. Supplementary Video 4
  5. Supplementary Video 5
  6. Supplementary Video 6
  7. Supplementary Video 7
  8. Supplementary Video 8