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Neural Plasticity
Volume 2010, Article ID 870573, 11 pages
http://dx.doi.org/10.1155/2010/870573
Research Article

Synaptic Remodeling in the Dentate Gyrus, CA3, CA1, Subiculum, and Entorhinal Cortex of Mice: Effects of Deprived Rearing and Voluntary Running

1Department of Biology, Bielefeld University, Universitätsstraße 25, 33615 Bielefeld, Germany
2Department of Biology, Humboldt University, Berlin, Germany
3Cluster of Excellence NeuroCure, Charité-Universitätsmedizin Berlin, Berlin, Germany

Received 12 December 2009; Revised 6 March 2010; Accepted 7 March 2010

Academic Editor: Michael Stewart

Copyright © 2010 Andrea T. U. Schaefers et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hippocampal cell proliferation is strongly increased and synaptic turnover decreased after rearing under social and physical deprivation in gerbils (Meriones unguiculatus). We examined if a similar epigenetic effect of rearing environment on adult neuroplastic responses can be found in mice (Mus musculus). We examined synaptic turnover rates in the dentate gyrus, CA3, CA1, subiculum, and entorhinal cortex. No direct effects of deprived rearing on rates of synaptic turnover were found in any of the studied regions. However, adult wheel running had the effect of leveling layer-specific differences in synaptic remodeling in the dentate gyrus, CA3, and CA1, but not in the entorhinal cortex and subiculum of animals of both rearing treatments. Epigenetic effects during juvenile development affected adult neural plasticity in mice, but seemed to be less pronounced than in gerbils.