Alterations of GABAergic Signaling in Autism Spectrum Disorders

Figure 2

Pairing GABA-mediated GDPs with Schaffer collateral stimulation persistently enhances synaptic strength at glutamatergic CA3-CA1 connections. (a) Experimental paradigm. (b) The rising phase of GDPs (between the dashed lines) was used to trigger synaptic stimulation (stim) (c) EPSCs evoked in CA1 principal cells by minimal stimulation of Schaffer collateral, before and after pairing (average of 19 responses). (d) Each bar represents the mean peak amplitude of synaptic responses including failures (𝑛=8) and the paired pulse ratio (PPR; 𝑛=8), obtained before (open) and after (closed) pairing. (Modified from [50]).

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