Review Article
Histaminergic Mechanisms for Modulation of Memory Systems
Table 3
Intracerebroventricular administration of drugs that act on the histaminergic system and memory performance.
| Species | Behavioral task | Histaminergic modulator | Lesion or pharmacological induced memory impairment | Effect on memory | Reference(s) |
| Rat | Passive avoidance | Histamine | | ↑ | [120, 121] | Rat | Passive avoidance | Histamine | | ↓ | [122–124] | Mouse | Passive avoidance | Histamine | Lithium (i.p.) | ↑ | [125] | Rat | Active avoidance | Histamine | | ↑ | [126] | Rat | Active avoidance | Histamine | | ↓ | [127] | Rat | Active avoidance | Histamine | Bilateral hippocampectomy (dorsal hippocampus) | ↑ | [128] | Rat | Active avoidance | Histamine | alpha-FMH (i.p.) | ↑ | [126] | Rat | Habituation in open field | Histamine | | ↑ | [121] | Rat | Social memory | Histamine | | ↑ | [129] | Rat | Social memory | Histidine | | ↑ | [129] | Rat | Social memory | alpha-FMH | | ↓ | [129] | Rat | Radial maze | Histamine | N-methyl- d-aspartate (NMDA) receptor glycine site antagonist (7-chlorokynurenic acid) i.c.v | ↑ | [130] | Rat | Radial maze | alpha-FMH | | ↓ | [131] | Rat | Passive avoidance | H1 receptor antagonist (chlorpheniramine) | | ↑ | [122] | Rat | Passive avoidance | H1 receptor antagonist (pyrilamine ) | | ↑ | [124] | Rat | Passive avoidance | H2 receptor antagonist (cimetidine) | | ↑ | [123, 124] | Mouse | Passive avoidance | H2 receptor agonist (4-methylhistamine) | | ↓ | [90] | Rat | Active avoidance | H1 receptor agonist (2-methylhistamine and 2-thiazolylethylamine) | | ↓ | [127] | Rat | Step-through active avoidance | H1 receptor agonist (2-methylhistamine) | | ↑ | [132] | Rat | Step-through active avoidance | H1 receptor antagonist (pyrilamine or diphenhydramine) | | ↓ | [132] | Rat | Social memory | H3 receptor agonist (immepip) | | ↓ | [129] | Rat | Social memory | H3 receptor antagonist (thioperamide) | | ↑ | [129] | Rat | Object recognition | H1 receptor agonist [2-(3-(trifluoromethyl)-phenyl)histamine] | | ↑ | [133] | Rat | Water maze | H1 receptor antagonist (chlorpheniramine) | | ↑ | [134] |
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alpha-FMH: alpha-fluoromethylhistidine (inhibitor of histamine decarboxylase) i.p. intraperitoneal i.c.v intracerebroventricular.
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