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Neural Plasticity
Volume 2011, Article ID 413543, 15 pages
http://dx.doi.org/10.1155/2011/413543
Research Article

Motor Cortical Networks for Skilled Movements Have Dynamic Properties That Are Related to Accurate Reaching

1Neuroscience Statistics Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
2Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
3Centre for Neuromuscular and Neurological Disorders, University of Western Australia, QEII Medical Centre, Nedlands, WA 6009, Australia
4Neuroscience Statistics Research Laboratory, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA

Received 15 February 2011; Revised 14 July 2011; Accepted 11 August 2011

Academic Editor: Johannes J. Letzkus

Copyright © 2011 David F. Putrino et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Neurons in the Primary Motor Cortex (MI) are known to form functional ensembles with one another in order to produce voluntary movement. Neural network changes during skill learning are thought to be involved in improved fluency and accuracy of motor tasks. Unforced errors during skilled tasks provide an avenue to study network connections related to motor learning. In order to investigate network activity in MI, microwires were implanted in the MI of cats trained to perform a reaching task. Spike trains from eight groups of simultaneously recorded cells (95 neurons in total) were acquired. A point process generalized linear model (GLM) was developed to assess simultaneously recorded cells for functional connectivity during reaching attempts where unforced errors or no errors were made. Whilst the same groups of neurons were often functionally connected regardless of trial success, functional connectivity between neurons was significantly different at fine time scales when the outcome of task performance changed. Furthermore, connections were shown to be significantly more robust across multiple latencies during successful trials of task performance. The results of this study indicate that reach-related neurons in MI form dynamic spiking dependencies whose temporal features are highly sensitive to unforced movement errors.