Altered GABA Signaling in Early Life Epilepsies

Table 3

Effects of early life seizures on 𝐺𝐴𝐵𝐴_𝐴 receptors and currents in rats.

Seizure model	Age	Region	Effects on GABAA receptors	Ref.
Ictal changes
In vivo SE (Lithium-pilocarpine; continuous hippocampal stimulation)	PN30	Hippocampus	Reduced surface expression of β2/3, γ2 subunits but not of δ.	[139]
In vivo SE (lithium-pilocarpine)	4–7 week old	Hippocampus	Internalization of β2/3, γ2 subunits; reduced mIPSCs	[140]
After seizures
Recurrent flurothyl seizures	PN1-5	Hippocampus, somatosensory cortex	Decreased amplitude of GABAergic IPSCs	[141, 142]
Flurothyl seizures	PN6 or PN6-10	Hippocampus	Decreased numbers of α1-ir neurons	[143]
Kainic acid SE	PN9	Hippocampus	At 3 weeks postictally: α1,; α4, γ2 decrease; α2, α3 increase; α5 increase (CA3 only); β3 increase compared to controls	[144]
Lithium-pilocarpine	PN10	Hippocampus (dentate gyrus)	In adulthood: increased α1 expression, larger GABA current, enhanced zolpidem sensitivity	[145]
Lithium-pilocarpine SE	PN20	Hippocampus	Decreased α1 and increased α4 expression in the hippocampus of epileptic versus non-epileptic rats	[146]