Review Article
Altered GABA Signaling in Early Life Epilepsies
Table 4
Effects of Seizures on CCCs.
| | Model | Species | Age at seizures | Region | Effects | Ref. |
| | Ictal changes |
| | Kainic acid | Rat | PN6-7 | Hippocampus | Switch from hyperpolarizing to depolarizing EGABA | [184] | | Low Mg2+ seizures | Mice | PN5 | Hippocampus | Bumetanide sensitive increase in [Cl-]i | [150] |
| | After seizures |
| | Kainic acid | Rat (male) | PN4-6 | Hippocampus (at least 4 days postictally) | Increased KCC2; decreased NKCC1 activity; more hyperpolarizing EGABA | [185] | | Kainic acid | Rat (female) | PN4-6 | Hippocampus (at least 4 days postictally) | No change in KCC2; increased NKCC1 activity; more depolarizing EGABA | [185] | | Kainic acid | Rat (male) | PN5-7 | Hippocampus (immediate postictal period) | Increased surface expression of KCC2; hyperpolarizing shift of EGABA | [171] |
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