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Neural Plasticity
Volume 2011, Article ID 641248, 8 pages
Research Article

Neurturin Evokes MAPK-Dependent Upregulation of Egr4 and KCC2 in Developing Neurons

1Neuroscience Center, University of Helsinki, Viikinkaari 4, 00014 Helsinki, Finland
2Institute of Biotechnology, University of Helsinki, Viikki Campus, Viikinkaari 9, 00014 Helsinki, Finland
3Inserm Unité 901, 13009 Marseille, France
4UMR S901 Aix-Marseille 2, Université de la Méditerranée, 13009 Marseille, France
5INMED/INSERM u901, 13009 Marseille, France
6Neuroscience Research Center, Charité-Universitätsmedizin, 10117 Berlin, Germany
7Experimental Animal Center, University of Helsinki, 00014 Helsinki, Finland

Received 28 February 2011; Accepted 3 June 2011

Academic Editor: Laura Cancedda

Copyright © 2011 Anastasia Ludwig et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The K-Cl cotransporter KCC2 plays a crucial role in the functional development of -mediated responses rendering GABA hyperpolarizing in adult neurons. We have previously shown that BDNF upregulates KCC2 in immature neurons through the transcription factor Egr4. The effect of BDNF on Egr4 and KCC2 was shown to be dependent on the activation of ERK1/2. Here we demonstrate that the trophic factor neurturin can also trigger Egr4 expression and upregulate KCC2 in an ERK1/2-dependent manner. These results show that Egr4 is an important component in the mechanism for trophic factor-mediated upregulation of KCC2 in immature neurons involving the activation of specific intracellular pathways common to BDNF and Neurturin.