From Abnormal Hippocampal Synaptic Plasticity in Down Syndrome Mouse Models to Cognitive Disability in Down Syndrome
Depiction of altered CA1 hippocampal plasticity in Ts65Dn mice. (a) Diagram indicating electrode placement for stimulating Schaffer collaterals arising from CA3 and recording the evoked field excitatory postsynaptic potential (EPSP) in CA1. Traces to the right indicate the typical change in evoked responses (red) following LTP and LTD. (b) Simulated data depicting suppressed LTP in Ts65Dn mice. After high-frequency stimulation of SC (at arrow head), the field EPSP increases and remains enhanced in euploid mice but fails to remain elevated in Ts65Dn mice. (c) Simulated LTD data depicting exaggerated depression of evoked EPSPs following low-frequency stimulation of SC in Ts65Dn mice. (Traces in B and C based on data from [44, 45].)
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