Intracellular Ca2+ Stores and Ca2+ Influx Are Both Required for BDNF to Rapidly Increase Quantal Vesicular Transmitter Release
Figure 2
The increase in mEPSC frequency requires TrkB receptor activation. (a) Top: representative trace showing the BDNF effect in a CA1 pyramidal cell in the presence of the receptor tyrosine kinase inhibitor k-252a (200 nM); left: representative running average plot of mEPSC frequency in the presence of k252a; right: mean frequency of mEPSCs before and after BDNF in the continuous presence of k252a. (b) Top: representative trace recorded showing the BDNF effect in a CA1 pyramidal cell dialyzed with k252b (200 nM), a membrane impermeable inhibitor of the Trk receptor family; left: running average plot of mEPSC frequency in a representative k252b-loaded neuron; right: mean frequency of mEPSCs before and after BDNF in k252b-loaded neurons.
