Tumor Necrosis Factor Alpha Mediates GABAA Receptor Trafficking to the Plasma Membrane of Spinal Cord Neurons In Vivo
Figure 6
Two-way interactions of drug dose and injection side. ((a)–(d)) There was a significant effect of dose across all outcomes (). High doses of TNFα had a widespread effect extending onto the contralateral side of the cord such that there was no effect of injection side across any outcome (). ((a)–(c)) A 2-factor mixed ANOVA revealed that there was not a significant interaction between dose and side on total GABAAR on the neuropil, synaptic GABAAR on the neuropil, or plasma membrane (); yet there was a significant effect of interaction for extrasynaptic GABAAR on the plasma membrane ((d) ).
