Neural Plasticity / 2012 / Article / Tab 1

Review Article

Synaptic Plasticity and Learning in Animal Models of Tuberous Sclerosis Complex

Table 1

Overview of available data on synaptic plasticity and memory.

Animal modelSynaptic plasticityLearning and memoryReferences

rat (Eker rat)Reduced theta-burst stimulation-induced early phase LTP at Schaffer collateral-CA1 synapses. Reduced low-frequency stimulation-induced LTD at Schaffer collateral-CA1 synapses.Enhanced episodic-like memory (water maze, radial maze). Mildly reduced exploration behavior (open field, novel object recognition, social exploration). No difference in anxiety-related behavior (light/dark box). No difference in hippocampus-dependent learning behavior (fear conditioning, water maze). [2628]
mouseEnhanced tetanus-induced late phase LTP at Schaffer collateral-CA1 synapses. No difference in tetanus-induced early phase LTP at Schaffer collateral-CA1 synapses. Reduced mGluR-dependent LTD at Schaffer collateral-CA1 synapses.Reduced hippocampus-dependent learning behavior (water maze, radial maze, context fear conditioning). [29, 30]
Dominant negative Tsc2 mutant mouse (ΔRG mouse)Reduced mGluR-dependent LTD at Schaffer collateral-CA1 synapses.Increased anxiety-related behavior (elevated plus maze). Mildly impaired hippocampus-dependent learning behavior (water maze, context fear conditioning). Impaired social interaction.[3133]
Tsc1 GFAP CKO mouseReduced tetanus-induced early phase LTP at Schaffer collateral-CA1 synapses.Reduced hippocampus-dependent learning behavior (water maze, context fear conditioning).[34]
Virus-injected mouse (Tsc1-deletion in CA1 neurons)Reduced mGluR-dependent LTD at Schaffer collateral-CA1 synapses.[35]
mouseReduced hippocampus-dependent learning behavior (water maze, context fear conditioning).[36]

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