Neural Plasticity / 2012 / Article / Tab 1

Research Article

Selective Estrogen Receptor Modulators Regulate Dendritic Spine Plasticity in the Hippocampus of Male Rats

Table 1

Numerical density of dendritic spines in hippocampal CA1 pyramidal neurons of male rats 24 hours after the treatment with vehicle, raloxifene, or tamoxifen.

VehicleRaloxifeneTamoxifen

Total spines161.0 ± 5.0258.2 ± 3.0a255.0 ± 4.0b
Thin74.8 ± 2.889.6 ± 3.8a78.0 ± 3.6c
Mushroom50.4 ± 1.884.6 ± 3.2a92.8 ± 1.6bc
Stubby28.6 ± 1.465.8 ± 1.8a 71.0 ± 2.2b
Wide6.2 ± 0.615.6 ± 1.0a11.8 ± 1.2bc
Branched0.4 ± 0.10.6 ± 0.20.6 ± 0.1
Double0.1 ± 0.040.04 ± 0.040.4 ± 0.1

Data represent mean ± SEM of the number of dendritic spines per 100 μm dendritic segment from 6 animals in each experimental group. Significant differences, ; araloxifene versus Vehicle;  btamoxifen versus. Vehicle; ctamoxifen versus Raloxifene.

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