Neural Plasticity / 2012 / Article / Tab 2

Research Article

Selective Estrogen Receptor Modulators Regulate Dendritic Spine Plasticity in the Hippocampus of Male Rats

Table 2

Proportion (%) of the different types of dendritic spines in hippocampal CA1 pyramidal neurons 24 hours after the treatment with vehicle, raloxifene, or tamoxifen.

VehicleRaloxifeneTamoxifen

Thin46.434.7a30.5b
Mushroom31.332.736.3bc
Stubby17.725.4a27.8b
Wide3.86.0a4.6
Branched0.20.20.2
Double0.070.010.1

Data represent means from 6 animals in each experimental group. Significant differences, ; araloxifene versus Vehicle;  btamoxifen versus Vehicle;  ctamoxifen versus raloxifene.

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