Selective Estrogen Receptor Modulators Regulate Dendritic Spine Plasticity in the Hippocampus of Male Rats

Table 2

Proportion (%) of the different types of dendritic spines in hippocampal CA1 pyramidal neurons 24 hours after the treatment with vehicle, raloxifene, or tamoxifen.

	Vehicle	Raloxifene	Tamoxifen
Thin	46.4	34.7^a	30.5^b
Mushroom	31.3	32.7	36.3^bc
Stubby	17.7	25.4^a	27.8^b
Wide	3.8	6.0^a	4.6
Branched	0.2	0.2	0.2
Double	0.07	0.01	0.1

Data represent means from 6 animals in each experimental group. a-cSignificant differences, 𝑃<0.05; ^araloxifene versus Vehicle;  ^btamoxifen versus Vehicle;  ^ctamoxifen versus raloxifene.