Spines, Plasticity, and Cognition in Alzheimer's Model Mice
Figure 1
In vivo multiphoton imaging of plaques (labeled with methoxy X-O4, blue), vasculature (labeled with Texas red dextran, red), and dendrites (transgenically expressing YFP, green) in mice transgenic for mutant human APP and PS1 crossed with YFP transgenic mice allow examination of dendritic spine plasticity and loss. Low-resolution three-dimensional image stacks (a) are used to repeatedly find the same imaging sites. Higher-resolution image stacks (b) are used for spine analysis. Scale bars 100 μm (a) 10 μm (b).
