Review Article
Spines, Plasticity, and Cognition in Alzheimer's Model Mice
Table 1
Progressive synaptic malfunction AD transgenic mice.
| Model | Mutations | Age (months) | Basal synaptic transmission | Long-term potentiation | Paired-pulse facilitation |
| | | 2-3 | | Impaired [73] | | Tg2576 | APPswe | 4–6 | Impaired [74] | Normal [74]/impaired [73] | | 6–12 | Impaired [75] | | Normal [75] | | | >12 | Normal [76, 77]/Impaired [75] | Normal [75]/impaired [76, 77] | Normal [4, 6] |
| | | <6 | Normal [78] | Impaired [78] | Impaired [78] | PDAPP | APP (V717F) | 6–12 | | | | | | >12 | Impaired [78] | Normal [78] | Impaired [78] |
| | | <6 | Normal [79] | Impaired [79, 80] | | APP/PS1 | APPswe/PS1dE9 | 6–12 | Impaired [79, 80] | Impaired [79, 80] | Normal [80] | | | >12 | | | |
| | | 1-2 | Normal [81] | Normal [81] | Normal [81] | 3xTg-AD | APPSwe, PS1M146V, and tauP301L | 3–6 | | | | 6–12 | Impaired [81] | Impaired [81] | Normal [81] | | | >12 | | | |
| 5XFAD | APPswe/lnd/fl and a PS1 transgene carrying double FAD mutations (M146L and L286V) | <6 | Normal [82] | Normal [82] | Normal [82] | 6–12 | Impaired [82, 83] | Impaired [82, 83] | Normal [82] | >12 | | | |
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