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Neural Plasticity
Volume 2012, Article ID 426437, 8 pages
Research Article

Modulation of CREB in the Dorsal Lateral Geniculate Nucleus of Dark-Reared Mice

1Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Center, 1101 E. Marshall Street, Richmond, VA 23298, USA
2Department of Biochemistry and Molecular Biology, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA

Received 12 September 2011; Accepted 4 October 2011

Academic Editor: Arianna Maffei

Copyright © 2012 Thomas E. Krahe et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The cAMP-response element-binding protein (CREB) plays an important role in visual cortical plasticity that follows the disruption of sensory activity, as induced by dark rearing (DR). Recent findings indicate that the dorsal lateral geniculate nucleus (dLGN) of thalamus is also sensitive to altered sensory activity. DR disrupts retinogeniculate synaptic strength and pruning in mice, but only when DR starts one week after eye opening (delayed DR, DDR) and not after chronic DR (CDR) from birth. While DR upregulates CREB in visual cortex, whether it also modulates this pathway in dLGN remains unknown. Here we investigate the role of CREB in the dLGN of mice that were CDR or DDR using western blot and immunofluorescence. Similar to findings in visual cortex, CREB is upregulated in dLGN after CDR and DDR. These findings are consistent with the proposal that DR up-regulates the CREB pathway in response to decreased visual drive.