Divergent Roles of p75NTR and Trk Receptors in BDNF's Effects on Dendritic Spine Density and Morphology

Figure 1

BDNF increases dendritic spine density and affects the proportion of morphological spine types. (a) Dendritic segment of a CA1 pyramidal neuron that was volume-rendered to illustrate individual spine geometrical dimensions and examples of different spine types. (b) Representative examples of dendritic segments of CA1 pyramidal neurons maintained in serum-containing media (SM) and treated with BDNF (250 ng/mL) for 48 hrs (scale bar represents 2 μm). (c) Dendritic spine density expressed per 10 μm of apical dendrite. (d) Proportion of each morphological type of dendritic spine, expressed as a fraction of the total spine population. *𝑃<0.05 and **𝑃<0.01, after an unpaired Student’s 𝑡-test.