Divergent Roles of p75NTR and Trk Receptors in BDNF's Effects on Dendritic Spine Density and Morphology
Figure 2
Role of Trk and in BDNF’s effects on dendritic spine density and morphology. (a) Representative examples of dendritic segments of CA1 pyramidal neurons maintained in serum-containing media (SM) and treated with the function-blocking antibody of , REX (50 μg/mL), and BDNF (250 ng/mL) for 48 hrs (scale bar represents 2 μm). (b) Dendritic spine density expressed per 10 μm of apical dendrite. (c) Proportion of each morphological type of dendritic spine, expressed as a fraction of the total spine population. (d) Representative examples of dendritic segments of CA1 pyramidal neurons maintained in SM and treated with k-252a (200 nM) and BDNF (250 ng/mL) for 48 hrs. (e) Dendritic spine density expressed per 10 μm of apical dendrite. (f) Proportion of each morphological type of dendritic spines, expressed as a fraction of the total spine population. *, **, and ***, after a one-way ANOVA.
