Mouse Models of Down Syndrome as a Tool to Unravel the Causes of Mental Disabilities

<table class="table-group" id="tab5"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td align="left"></td><td align="left">DS</td><td align="left">Ts65Dn</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td align="left">Neuroinflammation</td><td align="left">(i) Activated microglia and increased levels of proinflammatory cytokines</td><td align="left">(i) Activated microglia</td></tr><tr><td align="left" colspan="3"><hr/></td></tr><tr><td align="left">Oxidative stress</td><td align="left">(i) Increased</td><td align="left">(i) Increased</td></tr><tr><td align="left" colspan="3"><hr/></td></tr><tr><td align="left">AD neuropathology</td><td align="left">(i) Cholinergic neuron loss, plaques, and tangles</td><td align="left">(i) Cholinergic neuron degeneration, increased APP and <i>β</i>-amyloid levels</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Neurodegenerative processes in DS and in the Ts65Dn mouse.

Neural Plasticity

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Table 5

Table 5: Mouse Models of Down Syndrome as a Tool to Unravel the Causes of Mental Disabilities 