Animal Models of Psychiatric Disorders That Reflect Human Copy Number Variation

Figure 2

Schematic representation in studies applying chromosome engineering. Published in (a) Nakatani et al. [10], (b) Horev et al. [12], (c) Stark et al. [14]. The paternally, maternally expressed, and nonimprinting genes were labeled with blue, red, and black, respectively.

(a)  Mouse Chr. 7: 6.3 Mb duplication (Human Chr. 15p11-13)

(b) Mouse Chr. 7: 0.4 Mb deletion/duplication (Human Chr. 16p11)

(c) Mouse Chr. 16: 1.3 Mb deletion (Human Chr. 22q11)