Review Article
Understanding the Pathogenesis of Angelman Syndrome through Animal Models
Table 2
Cellular functions regulated by UBE3A.
| Identified substrates | Cellular functions |
| HHR 23A, Src family tyrosine kinase Blk, P53, P27, PML tumor suppressor [48–52]. | Cell growth and differentiation | Steroid hormone receptors like androgen receptor, glucocorticoid receptor, mineralocorticoid receptor [45, 46, 84]. | Coactivator of steroid hormone receptors | Arc, RhoA-GEF ephexin5, Rho-GEF Pbl/ECT2 [54–58]. | Synaptic function and plasticity | Polyglutamine proteins, α-synuclein, misfolded proteins [59–61]. | Cellular protein quality control |
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Number in the brackets indicates references.
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