The Gain Modulation by N-methyl-D-aspartate in the Projection Neurons of Robust Nucleus of the Arcopallium in Adult Zebra Finches
Figure 1
(a) Traces of action potentials in response to 1 s current steps of 10, 50, and 90 pA (top to bottom). The average frequencies were 8.98, 18.54, and 27.05 Hz, respectively, before NMDA application (left column); NMDA increased the frequency and the average frequencies were 8.72, 23.62, and 33.34 Hz after application of NMDA (20 μM) for 8 min (middle column); the effects were reversed after wash for 15 min (right column). (b) The slope of the f-I relationships was changed after 20 μM NMDA application when depolarizing current steps from 0 to 90 pA. The slopes were , , and Hz/nA for the control, NMDA treatment, and wash, respectively (, ). 20 μM NMDA increased the gain of RA projection neurons. The average in control is shown as open squares, group in NMDA is shown as open circles, and the group after wash is shown as open diamonds.
