GluN3A: An NMDA Receptor Subunit with Exquisite Properties and Functions

Figure 2

Schematic of the proposed distribution of GluN3A-containing NMDAR in the pre- and postsynaptic sites as well as on astrocytic processes. Endocytosis of GluN3A is activity dependent, driving PACSIN1 binding and Src phosphorylation of the YWL motif to selectively internalize GluN3A-containing NMDAR. Other molecular interactions with GluN3A could play roles in trafficking of the receptor subunit and dendritic spine dynamics. The roles of GluN3A in astrocytic processes still remain unclear but it could potentially exert an attenuating effect on calcium entry in a reciprocal manner to mGluR calcium entry.