Table 1: Behavioral, electrophysiological, and molecular phenotypes in mice with iDG.

-CaMKII HKO [1]Shn-2 KO [2] SNAP-25 KI [3]CN KO [4, 10, 21]FLX treatment [5]Pilocarpine treatment [6]

Behavioral
phenotypes
Locomotor activity [29]
Working memory [112] [6, 30]
Social interactionMutants kill cagemates
PPI

Electrophysiological phenotypesMossy fibre-CA3 synapse
Basal transmission
Frequency facilitation
Granule cell soma
Passive
 Input resistance
Active
 Excitability
 Spike number

Molecular
phenotypes
Markers of immature granule cells
Dopamine D1 receptor (Drd1a) [31]
Calretinin
Markers of mature granule cells
Tryptophan 2,3-dioxygenase (Tdo2)
Desmoplakin (Dsp)
Calbindin
GluR1 [32]
Immediate early genes induction
c-Fos or Arc-dVenus [1, 13]
Inflammation-related molecules
Glial fibrillary acidic protein (GFAP) [31] [33]
Complement components [31] [34]
MHC genes [31] [34]
Adult neurogenesis
BrdU incorporation [25] [33, 35]

↑: Increased or upregulated.
: Decreased or downregulated.
—: Nonsignificant.