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Neural Plasticity
Volume 2013 (2013), Article ID 321685, 7 pages
http://dx.doi.org/10.1155/2013/321685
Research Article

The Plasma Membrane Ca2+-ATPase2 (PMCA2) Is Involved in the Regulation of Purkinje Cell Dendritic Growth in Cerebellar Organotypic Slice Cultures

Anatomical Institute, Department of Biomedicine, University of Basel, Pestalozzistraße 20, 4056 Basel, Switzerland

Received 4 July 2013; Revised 30 August 2013; Accepted 3 September 2013

Academic Editor: Rachel M. Sherrard

Copyright © 2013 Pradeep Sherkhane and Josef P. Kapfhammer. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. P. Kapfhammer, “Cellular and molecular control of dendritic growth and development of cerebellar Purkinje cells,” Progress in Histochemistry and Cytochemistry, vol. 39, no. 3, pp. 131–182, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. K. Fujishima, R. Horie, A. Mochizuki, and M. Kengaku, “Principles of branch dynamics governing shape characteristics of cerebellar Purkinje cell dendrites,” Development, vol. 139, pp. 3442–3455, 2012. View at Publisher · View at Google Scholar
  3. F. Metzger and J. P. Kapfhammer, “Protein kinase C activity modulates dendritic differentiation of rat Purkinje cells in cerebellar slice cultures,” European Journal of Neuroscience, vol. 12, no. 6, pp. 1993–2005, 2000. View at Publisher · View at Google Scholar · View at Scopus
  4. K. Schrenk, J. P. Kapfhammer, and F. Metzger, “Altered dendritic development of cerebellar Purkinje cells in slice cultures from protein kinase Cγ-deficient mice,” Neuroscience, vol. 110, no. 4, pp. 675–689, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Sirzen-Zelenskaya, J. Zeyse, and J. P. Kapfhammer, “Activation of class I metabotropic glutamate receptors limits dendritic growth of Purkinje cells in organotypic slice cultures,” European Journal of Neuroscience, vol. 24, no. 11, pp. 2978–2986, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. O. S. Gugger, J. Hartmann, L. Birnbaumer, and J. P. Kapfhammer, “P/Q-type and T-type calcium channels, but not type 3 transient receptor potential cation channels, are involved in inhibition of dendritic growth after chronic metabotropic glutamate receptor type 1 and protein kinase C activation in cerebellar Purkinje cells,” European Journal of Neuroscience, vol. 35, no. 1, pp. 20–33, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. H. Huang, R. Y. Nagaraja, M. L. Garside, W. Akemann, T. Knöpfel, and R. M. Empson, “Contribution of plasma membrane Ca ATPase to cerebellar synapse function,” World Journal of Biological Chemistry, vol. 1, pp. 95–102, 2010. View at Publisher · View at Google Scholar
  8. Y. T. Kim, Y. L. Namkung, J. Kwak, and C. K. Suh, “Involvement of Na+-Ca2+ exchanger on metabotropic glutamate receptor 1-mediated [Ca2+]i transients in rat cerebellar Purkinje neurons,” Neuroscience, vol. 146, no. 1, pp. 170–177, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. C. J. Roome, T. Knöpfel, and R. M. Empson, “Functional contributions of the plasma membrane calcium ATPase and the sodium-calcium exchanger at mouse parallel fibre to Purkinje neuron synapses,” Pflügers Archiv, vol. 465, no. 2, pp. 319–331, 2013. View at Publisher · View at Google Scholar
  10. A. G. Filoteo, N. L. Elwess, A. Enyedi, A. Caride, H. H. Aung, and J. T. Penniston, “Plasma membrane Ca2+ pump in rat brain. Patterns of alternative splices seen by isoform-specific antibodies,” Journal of Biological Chemistry, vol. 272, no. 38, pp. 23741–23747, 1997. View at Publisher · View at Google Scholar · View at Scopus
  11. D. E. Hillman, S. Chen, R. Bing, J. T. Penniston, and R. Llinas, “Ultrastructural localization of the plasmalemmal calcium pump in cerebellar neurons,” Neuroscience, vol. 72, no. 2, pp. 315–324, 1996. View at Publisher · View at Google Scholar · View at Scopus
  12. V. A. Street, J. W. McKee-Johnson, R. C. Fonseca, B. L. Tempel, and K. Noben-Trauth, “Mutations in a plasma membrane Ca2+-atpase gene cause deafness in deafwaddler mice,” Nature Genetics, vol. 19, no. 4, pp. 390–394, 1998. View at Publisher · View at Google Scholar · View at Scopus
  13. T. Ueno, K. Kameyama, M. Hirata et al., “A mouse with a point mutation in plasma membrane Ca2+-ATPase isoform 2 gene showed the reduced Ca2+ influx in cerebellar neurons,” Neuroscience Research, vol. 42, no. 4, pp. 287–297, 2002. View at Publisher · View at Google Scholar · View at Scopus
  14. P. J. Kozel, R. A. Friedman, L. C. Erway et al., “Balance and hearing deficits in mice with a null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2,” Journal of Biological Chemistry, vol. 273, no. 30, pp. 18693–18696, 1998. View at Publisher · View at Google Scholar · View at Scopus
  15. K. H. Adcock, F. Metzger, and J. P. Kapfhammer, “Purkinje cell dendritic tree development in the absence of excitatory neurotransmission and of brain-derived neurotrophic factor in organotypic slice cultures,” Neuroscience, vol. 127, no. 1, pp. 137–145, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. J. P. Kapfhammer, “Cerebellar slice cultures,” in Biovalley Monographs, P. Poindron, P. Piguet, and E. Förster, Eds., vol. 1, pp. 74–81, Karger, Basel, Switzerland, 2005. View at Google Scholar
  17. J. P. Kapfhammer and O. S. Gugger, “The analysis of Purkinje cell dendritic morphology in organotypic slice cultures,” Journal of Visualized Experiments, vol. 61, no. 61, Article ID e3637, 2012. View at Google Scholar
  18. M. M. Usowicz, M. Sugimori, B. Cherksey, and R. Llinas, “P-type calcium channels in the somata and dendrites of adult cerebellar Purkinje cells,” Neuron, vol. 9, no. 6, pp. 1185–1199, 1992. View at Publisher · View at Google Scholar · View at Scopus
  19. M. E. Hildebrand, P. Isope, T. Miyazaki et al., “Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines,” Journal of Neuroscience, vol. 29, no. 31, pp. 9668–9682, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Watanabe, H. Takagi, T. Miyasho et al., “Differential roles of two types of voltage-gated Ca2+ channels in the dendrites of rat cerebellar Purkinje neurons,” Brain Research, vol. 791, no. 1-2, pp. 43–55, 1998. View at Publisher · View at Google Scholar · View at Scopus
  21. P. Isope and T. H. Murphy, “Low threshold calcium currents in rat cerebellar Purkinje cell dendritic spines are mediated by T-type calcium channels,” Journal of Physiology, vol. 562, no. 1, pp. 257–269, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. P. Isope, M. E. Hildebrand, and T. P. Snutch, “Contributions of T-type voltage-gated calcium channels to postsynaptic calcium signaling within Purkinje neurons,” Cerebellum, vol. 11, no. 3, pp. 651–665, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. J. Kitano, M. Nishida, Y. Itsukaichi et al., “Direct interaction and functional coupling between metabotropic glutamate receptor subtype 1 and voltage-sensitive Cav2.1 Ca2+ channel,” Journal of Biological Chemistry, vol. 278, no. 27, pp. 25101–25108, 2003. View at Publisher · View at Google Scholar · View at Scopus
  24. J. Johnston and K. R. Delaney, “Synaptic activation of T-Type Ca2+ channels via mGluR activation in the primary dendrite of mitral cells,” Journal of Neurophysiology, vol. 103, no. 5, pp. 2557–2569, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. R. M. Empson, M. L. Garside, and T. Knöpfel, “Plasma membrane Ca2+ ATPase 2 contributes to short-term synapse plasticity at the parallel fiber to Purkinje neuron synapse,” Journal of Neuroscience, vol. 27, no. 14, pp. 3753–3758, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. R. M. Empson, W. Akemann, and T. Knöpfel, “The role of the calcium transporter protein plasma membrane calcium ATPase PMCA2 in cerebellar Purkinje neuron function,” Functional Neurology, vol. 25, no. 3, pp. 153–158, 2010. View at Google Scholar · View at Scopus