Microglia and Synapse: Interactions in Health and Neurodegeneration
Figure 3
Microglial accumulation of phagocytic inclusions during aging and age-associated loss of sensory function. Examples of Iba1-immunostained microglia containing (a) accumulation of cellular inclusions from the phagocytic elimination of neurons or glial cells and (b) a single cellular inclusion that resembles an axonal terminal with clearly visible synaptic vesicles (inset) in the visual cortex of a 20-month-old mouse with age-associated loss of visual function. Scale bars: 1000 nm. Reproduced from Tremblay et al. [31].
