Neural Plasticity and Proliferation in the Generation of Antidepressant Effects: Hippocampal Implication
Figure 4
Western blot analyses of hippocampal CREB (a) and p-CREB (b) levels and ratio p-CREB/CREB (c) after chronic antidepressant treatment (14 days) with fluoxetine (10 mg/kg/day) and venlafaxine (40 mg/kg/day). Note that p-CREB levels and ratio p-CREB/CREB are increased after fluoxetine treatment, but not total CREB, or after venlafaxine treatment in total cell lysate from hippocampus of rats. Values are means ± S.E.M. Corresponding to densitometry levels of the proteins expressed as the percentage of the same proteins in vehicle-treated animals. * versus vehicle. Modified from Mostany et al., 2008 [10], and Mato et al., 2010 [100].
