Enhanced Expression of NR2B Subunits of NMDA Receptors in the Inherited Glaucomatous DBA/2J Mouse Retina

<table><i>Changes in expression of Brn-3a of DBA/2J mice at various ages.</i> (a) Representative immunoblots showing the changes of Brn-3a levels in DBA/2J and C57BL/6 mice at ages of 3, 6, 9, and 12 months. (b) Bar chart showing the average densitometric quantification of immunoreactive bands of Brn-3a in DBA/2J and C57BL/6 mice at ages of 3, 6, 9, and 12 months, respectively. <svg height="13.95" id="M113" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 71.987503 13.95" width="71.987503" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> versus 3-month-old C57BL/6 mice; <svg height="15.775" id="M114" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 75.449997 15.775" width="75.449997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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<g transform="matrix(.017,-0,0,-.017,16.8,15.5)"><path d="M619 482q0 -69 -40.5 -119t-96 -72.5t-118.5 -26.5h-44l-70 20l-31 -151q-14 -67 0.5 -83t89.5 -22l-5 -28h-287l8 28q65 7 81.5 22t29.5 83l79 398q12 56 0.5 70.5t-78.5 20.5l7 28h255q108 0 164 -43t56 -125zM524 478q0 141 -146 141q-25 0 -47 -8q-16 -6 -20.5 -13.5
t-10.5 -39.5l-43 -241q37 -13 83 -13q67 0 125.5 45t58.5 129z" id="x1D443"></path></g><g transform="matrix(.017,-0,0,-.017,32.32,15.5)"><path d="M512 -3l-437 233v51l437 233v-58l-378 -200v-2l378 -199v-58z" id="x3C"></path></g><g transform="matrix(.017,-0,0,-.017,47.024,15.5)"><path d="M241 635q53 0 94 -28.5t63.5 -76t33.5 -102.5t11 -116q0 -58 -11 -112.5t-34 -103.5t-63.5 -78.5t-94.5 -29.5t-95 28t-64.5 75t-34.5 102.5t-11 118.5q0 58 11.5 112.5t34.5 103t64.5 78t95.5 29.5zM238 602q-32 0 -55.5 -25t-35.5 -68t-17.5 -91t-5.5 -105
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</svg> versus 3-month-old DBA/2J mice; <svg height="16.3125" id="M115" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 67.800003 16.3125" width="67.800003" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.012,-0,0,-.012,.062,7.888)"><path d="M717 427v-28q-49 -6 -68.5 -20t-47.5 -55l-46.5 -70l-40.5 -63q40 -39 91.5 -100t71.5 -100l-7 -9q-38 3 -75 16.5t-47 24.5q-39 46 -87 95q-99 -132 -210 -132q-89 0 -143 55t-54 126q0 41 19.5 75t44 54.5t70.5 53.5q11 7 16 11q-72 67 -72 139q0 67 48.5 112.5
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<g transform="matrix(.017,-0,0,-.017,9.15,16.05)"><path d="M619 482q0 -69 -40.5 -119t-96 -72.5t-118.5 -26.5h-44l-70 20l-31 -151q-14 -67 0.5 -83t89.5 -22l-5 -28h-287l8 28q65 7 81.5 22t29.5 83l79 398q12 56 0.5 70.5t-78.5 20.5l7 28h255q108 0 164 -43t56 -125zM524 478q0 141 -146 141q-25 0 -47 -8q-16 -6 -20.5 -13.5
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</svg> versus age-matched C57BL/6 mice.</table>

Neural Plasticity

fig4

Figure 4

Figure 4: Enhanced Expression of NR2B Subunits of NMDA Receptors in the Inherited Glaucomatous DBA/2J Mouse Retina 