Neurogenesis, Exercise, and Cognitive Late Effects of Pediatric Radiotherapy
Figure 3
Data from our group showing RT-induced cognitive deficits. (a) Schematic illustration of the 5-CSRTT apparatus. (b) Fractionated X-ray radiation (4 Gy/d for 5 days) restricted to the frontal cortex of young rats significantly reduced choice accuracy on a 5-CSRTT 6 and 9 months following RT (*). (c) Fractionated WBI in young rats impaired pliancy on a hippocampus-dependent strategy-switching task in the Morris water maze [33] 3-4 weeks following RT (*).
