Neurogenesis, Exercise, and Cognitive Late Effects of Pediatric Radiotherapy
Figure 4
This diagram depicts a cross section of brain parenchyma showing the structure of the BBB and the damage induced by RT. (a) Normal BBB showing intact tight junctions (TJ), lack of vesicles, astrocytes and pericytes abutting the EC providing additional barrier support, and a neuron with thick, healthy myelin. (b) Damaged BBB in which astrocytes and pericytes have pulled away from the EC, a leukocyte has adhered to the EC, and there is formation of vesicles and loss of TJ integrity.
