Activation of Glycine and Extrasynaptic GABAA Receptors by Taurine on the Substantia Gelatinosa Neurons of the Trigeminal Subnucleus Caudalis
Figure 5
Taurine-induced inward current is only sensitive to gabazine at high concentration on SG neurons. (a), (c), (e) The representative traces showing the responses to taurine (100 μM and 1,000 μM) were not affected by gabazine 3 μM but were affected by gabazine 50 μM. (b), (d), (f) Bar graphs showing no significant difference about mean inward currents between the application taurine alone and taurine in the presence of gabazine 3 μM (), but there was a considerable change in the presence of gabazine 50 μM (). (g) The representative trace showing the inhibition of taurine-induced inward current in the presence of gabazine by GABAA broad antagonist bicuculline (20 μM). (h) The bar graph showing the mean inward current induced by taurine 1,000 μM in the presence of gabazine 3 μM and the mean remaining response after being blocked by bicuculline 20 μM (). Holding potential was −60 mV.
