Presynaptic Glycine Receptors Increase GABAergic Neurotransmission in Rat Periaqueductal Gray Neurons

Figure 5

Effect of Cd²⁺ on glycine-induced increase in sEPSC frequency. (a) Typical traces of glutamatergic sEPSCs observed during the application of 100 μM glycine in the absence (upper) and presence (lower) of 200 μM Cd²⁺. (b) Glycine-induced changes in frequency (A) and amplitude (B) of sEPSC in the absence and presence of Cd²⁺. Note that the glycine-induced facilitation of sEPSC frequency was completely suppressed by Cd²⁺. Each column was the mean and SEM from 7 neurons. **𝑃<0.01; n.s.: not significant.

(a)

(b)