System Consolidation of Spatial Memories in Mice: Effects of Enriched Environment

Figure 2

(a) c-Fos expression in subregions of dHPC for EE (open columns) and SC (filled columns) mice subjected to recall probe tests at 1, 10, 20, 30, and 50 days. DG: two-way ANOVA post hoc analysis Holm-Sidak method, SC versus EE, 𝑃=0.968; HC-SC versus HC-EE, 𝑃=0.503; SC versus HC-SC and EE versus HC-EE 𝑃<0.05 for all retention intervals. Statistical differences for factor day were found between 1 and 20 days, 1 and 30 days, and 50 days versus 20 and 30 days, all 𝑃<0.05. dCA1: two-way ANOVA post hoc analysis Holm-Sidak method, SC versus EE, 𝑃=0.242; HC-SC versus HC-EE 𝑃=0.979. Statistical difference factor day were found between 1 and 10, 20 and 30 days, all 𝑃<0.05. ^■Statistical significance between EE and HC-EE; ^□statistical significance between SC and HC-SC; ^∘statistical significance for factor day; error bars = s.e.m. (b) Representative panel of c-Fos protein expression in DG for EE and SC animals, for all recall probe tests; scale bar 100 𝜇m.

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