BACE1 Is Necessary for Experience-Dependent Homeostatic Synaptic Plasticity in Visual Cortex

Table 1

Comparison of mEPSC and neuronal parameters across experimental groups.

Genotype	Group	Frequency (Hz)	Amplitude (pA)	Rise time (ms)	Decay (𝜏, ms)	Series 𝑅 (MΩ)	Input 𝑅 (MΩ)	RMS Noise
WT	NR; (𝑛 = 9;3)	3.3±0.6	9.2±0.4	1.7±0.05	3.1±0.1	23.2±0.6	179±18	1.6±0.05
	DE; (𝑛 = 10;4)	2.4±0.2	13.9±1.0^∗	1.6±0.04	3.1±0.1	20.8±1.3	346±83	1.7±0.04
	LE; (𝑛 = 9;3)	3.2±0.4	10.4±0.3	1.6±0.09	3.0±0.2	21.2±1.6	238±39	1.6±0.06
KO	NR; (𝑛 = 9;3)	2.5±0.3	11.7±0.6	1.5±0.09	3.1±0.2	22.9±0.7	192±36	1.6±0.06
	DE; (𝑛 = 11;4)	3.3±0.5	12.8±0.8	1.6±0.06	3.2±0.1	21.2±0.9	220±26	1.6±0.06
	LE; (𝑛 = 9;3)	4.5±0.8	12.4±1.1	1.6±0.05	3.0±0.3	19.4±1.2	244±39	1.6±0.09

Values represent mean ± standard error of each measured parameter from neurons (𝑛: number of neurons). 𝑅: resistance. *Statistically significant difference from other groups within a genotype as determined by 𝑃<0.05 from one-factor ANOVA followed by Newman-Keuls Multiple Comparison post hoc test. 𝑛: number of cells; number of animals, 2-3 slices per mouse.