|
Reference | Animal model | Inflammation-stimulating agent | Time of exposure | Time of neurogenesis assessment | Effect on proliferation | Effect on survival | Effect on differentiation | Behavioural correlates | Evidence of underlying cellular mechanism |
|
Cui et al., (2009) [47] | Pregnant Sprague-Dawley rats | LPS 0.1 mg/kg | GD 15/16 | PND 14 | Decrease | No significant effect | No effect |
n/a |
n/a |
LPS 0.05 mg/kg | GD 18/19 | PND 14 PND 60 for both | n/a No effect | Decrease in prolif/survival1 No effect | No effect No effect |
|
Graciarena et al., (2010) [44] | Pregnant Wistar rats | LPS 0.5 mg/kg | GD 14–20 repeated injections every other day | PND 60 | Decrease | No effect | Decrease in the number of cells becoming young and mature neurons | Impaired recognition memory in novel object recognition task | Microglial activation specific for DG; TGFβ 1 decrease in the DG |
|
Graciarena et al., (2013) [49] | Pregnant Wistar rats | LPS 0.5 mg/kg | GD 14–20 repeated injections every other day | PND 60 | Decrease in cell proliferation | No effect | Decrease in the number of cells becoming young and mature neurons |
n/a | Microglial activationand TGFβ 1 and Smad2/3 pathway involvement |
Adult offspring | LPS 1 mg/kg | PND 60–68 injections every other day | PND 68 | Decrease | No effect | Transient microglial activation, no change in TGFβ 1 |
PND 120 | | |
No effect | |
| | | |
|
Järlestedt et al., (2013) [51] |
C57BL6 mice |
LPS 1 mg/kg |
PND 9 |
PND 41
|
Decrease |
n/a |
Decrease in the number of neurons and astrocytes |
n/a |
n/a |
PND 60 | n/a | Decrease in prolif/survival specific for dorsal hippocampus |
n/a |
|
Jiang et al., (2012, 2013) [53, 54] | Pregnant Sprague-Dawley rats | E. coli (endocervical injection) |
GD 15 | PND 3, 7, 14, 28 | Increase peaked at PND 7 | n/a | n/a | n/a | Increase in BDNF and TrkB protein levels in the hippocampus |
PND 28 | No change | No effect | No effect | Impaired spatial learning in MWM task | Normalised BDNF and TrkB protein content |
|
Lin and wang (2014) [50] | Pregnant Sprague-Dawley rats | LPS 0.066 mg/kg | GD 10.5 | PND 21 PND 90 | Decrease Decrease | No effect No effect | Decrease in the number of young neurons Decrease in the number of young neurons | Increased expression of depressive-like behaviours | n/a |
|
Meyer et al., (2006) [42] | Pregnant C57BL6 mice | Poly I:C 5 mg/kg | GD 9 | PND 24 | n/a | n/a | Increased number of young neurons in subgranular and outer granular layer | Increased adulthood anxiety in OF | Increased reelin in hippocampus |
GD 17 | PND 24 | | |
Increased number of young neurons in outer granular layer of DG | Perseveration-like behaviour | Increased Caspase-3 in hippocampus |
|