Effect of the Entorhinal Cortex on Ictal Discharges in Low-Mg²⁺-Induced Epileptic Hippocampal Slice Models

Figure 2

Initiation and propagation of interictal discharges in hippocampal slices. (a) An image of a hippocampal slice mounted on MEA. (b) Contour plot of averaged time delays of the FP relative to signals recorded by electrode number 23. The 𝑋 and 𝑌 coordinates denote the positions of electrodes. (c) The relative time delay of first negative peak of FP recorded along the stratum pyramidale. The interictal discharges initiated from the CA3a region and propagated bidirectionally to the CA1 region (anterograde) and the CA3c region (retrograde). (d) Averaged propagation speeds of interictal discharges in hippocampal slices (𝑃>0.05, paired t-test, 𝑛=5).

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