Effect of the Entorhinal Cortex on Ictal Discharges in Low-Mg²⁺-Induced Epileptic Hippocampal Slice Models

Figure 9

Effects of VPA on the epileptiform discharges in the EC and CA1 areas of the combined slices. (a) Long-term display of the effects of VPA (before, during, and after VPA application) on the discharge patterns in the EC and CA1 areas of an example of a combined slice. (b) The statistical analysis of VPA effects on duration of interictal discharges in CA1. There were no significant differences between the VPA group and the Control/Wash (𝑃>0.05, ANOVA, 𝑛=5). (c) The statistical analysis of VPA effects on frequency of interictal discharges in the CA1. There were significant differences between the VPA group and the Control/Wash (^∗𝑃<0.05, ANOVA, 𝑛=5).

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