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Neural Plasticity
Volume 2014, Article ID 254574, 11 pages
Research Article

G-Protein Coupled Receptor-Evoked Glutamate Exocytosis from Astrocytes: Role of Prostaglandins

Department of Fundamental Neurosciences, Faculty of Biology and Medicine, University of Lausanne, rue du Bugnon 9, 1005 Lausanne, Switzerland

Received 4 October 2013; Accepted 16 December 2013; Published 16 January 2014

Academic Editor: Emma Victoria Jones

Copyright © 2014 Corrado Cali et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Activation of purinergic P2Y1 receptors with a specific agonist 2MeSADP (20 μM) stimulates glutamate exocytosis as measured by number of fusion events (Suppl. fig. 1a). This can be reduced (by about 50%) by pre-incubating astrocytes with an anti-PGE2 antibody (Suppl. fig. 1b) thus supporting the DHPG data (Fig. 5)

  1. Supplementary Figure