Downregulated GABA and BDNF-TrkB Pathway in Chronic Cyclothiazide Seizure Model

Figure 5

Decreased GAT-1 staining in hippocampus of recurrent seizure rats 6 months after seizure induction by CTZ. (a-b) Pictures showing GAT-1 positive cells (arrow indicated) in left (a) and right (b) hippocampus from rats 6 months after either DMSO (top) or CTZ (bottom) treatment. (c-d) Group data showing significant decreases of the GAT-1 staining cells in CA1, CA3, and DG area of the hippocampus from rats 6 months after either DMSO (𝑛=3) or CTZ (𝑛=3) treatment. *𝑃<0.05, **𝑃<0.01, and ***𝑃<0.001 compared to the DMSO control group. Scale bar in (a) and (b): 200 μm.

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